Antidepressant drugs increased the risk, compared to placebo, of suicidal thinking and behaviour (suicidality) in children, adolescents and young adults in short-term studies of major depressive disorder (MDD) and other psychiatric disorders. Anyone considering the use of EXINUS PLUS or any other antidepressant in a child, adolescent or young adult must balance this risk with the clinical need. Short-term studies did not show an increase in the risk of suicidality with antidepressants, compared to placebo, in adults beyond age 24; there was a reduction in risk with antidepressants compared to placebo in adults aged 65 years and older. Depression and certain other psychiatric disorders are themselves associated with increases in the risk of suicide. Patients of all ages who are started on antidepressant therapy should be monitored appropriately and observed closely for clinical worsening, suicidality, or unusual changes in behaviour. Families and caregivers should be advised about the need for close observation and communication with the prescriber EXINUS PLUS is not approved for use in paediatric patients less than 12 years of age.
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Escitalopram is an antidepressant belonging to a group of drugs called selective serotonin reuptake inhibitors (SSRIs). It affects chemicals in the brain that may be unbalanced in people with depression or anxiety. Escitalopram is used to treat major depressive disorder in adults and adolescents at least 12 years old. Escitalopram is also used to treat anxiety in adults.
Clonazepam belongs to a group of medicines called benzodiazepines. It works by increasing levels of a calming chemical, gamma-amino-butyric-acid (GABA), in your brain. Depending on your health condition, this can relieve anxiety, stop seizures and fits or relax tense muscles. Clonazepam is used to prevent and control seizures. This medication is known as an anticonvulsant or antiepileptic drug. It is also used to treat panic attacks. Clonazepam works by calming your brain and nerves.
Clonazepam + Escitalopram Oxalate is a combination of two medicines: Clonazepam and escitalopram, which has anxiety-lowering and mood-enhancing effects. Clonazepam is a benzodiazepine (BZD) which increases the action of GABA, a chemical messenger that suppresses the abnormal activity of the nerve cells in the brain. Escitalopram is selective serotonin reuptake inhibitor (SSRI) which increases the levels of serotonin, a chemical messenger that improves mood.
Nausea, Vomiting, Diarrhea, Confusion, Uncoordinated body movements, Drowsiness, Tiredness, Delayed ejaculation, Anorgasmia (decreased orgasm), Low sexual desire, Memory impairment
